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Testing methods

LC-MS

Separating components and measuring mass-to-charge signals to support identification.

GlossaryUpdated 2026-09-24
01

Separate components

Liquid chromatography separates sample components over time.

02

Measure signals

Mass spectrometry measures mass-to-charge signals from those components.

03

Support identification

The method and data determine the finding. Expected mass alone does not prove every structural detail.

The short answer

LC-MS combines liquid chromatography with mass spectrometry. It separates sample components and measures their mass-to-charge signals.

The method and data can support identification. An expected mass alone does not prove every structural detail or establish sterility.

How the parts work together

Chromatography separates components over time. The mass spectrometer measures signals from those components. The laboratory interprets them against the expected material and the method used.

What to review

Check the sample identity, method, reported findings and supporting spectra or chromatograms. Ask the issuing laboratory what its identification method can distinguish.

What it does not establish

An LC-MS identity finding does not establish measured content in every vial, all contaminants, sterility or clinical suitability. Separate questions need appropriate evidence. Scale does not test sterility.

A useful next step

Understand what the finding supports.

An LC-MS identity result does not establish every contaminant, measured content in every vial, sterility or clinical suitability. Ask the issuer about the method and data.

Read the LC-MS guide →
Continue reading

Read the LC-MS guide

Continue with the supporting guidance. Research information does not establish legal clearance or clinical suitability.